LASER -OSTEOPEROSE Osteoblaster produserer
et stoff som heter temoxoline barbebutenol av osteoid, som hovedsakelig
består av type I kollagen. Osteoblaster er også ansvarlig for
mineralisering av denne matrisen. Sink, kobber og natrium er noen
av de mineralene som kreves i denne prosessen. Bein er dynamisk vev som
stadig blir omformet av osteoblaster, som er ansvarlig for produksjon
av matrix og mineral, og osteoklaster, som bryter ned vevet. Antallet
osteoblaster har tendens til å avta med alderen, og påvirke balansen
mellom dannelse og resorpsjon i benvev, og som potensielt kan føre til
osteoporose.
Lasers Med Sci. 2012 Jun 6. [Epub ahead of print] Effects of low-level laser therapy (LLLT) on bone repair in rats: optical densitometry analysis. Barbosa D, de Souza RA, Xavier M, da Silva FF, Arisawa EA, Villaverde AG.
The aim of this study was to evaluate
the process of bone repair in rats submitted to low-level laser therapy
using optical densitometry. A total of 45 rats which underwent femoral
osteotomy were randomly distributed into three groups: control (group I)
and laser-treated groups using wavelengths in the red (?, 660-690 nm)
and in the infrared (?, 790-830 nm) spectra (group II and group III,
respectively). The animals (five per group) were killed after 7, 14, and
21 days and the femurs were removed for optical densitometry analysis.
Optical density showed a significant increase in the degree of
mineralization (gray level) in both groups treated with the laser after 7
days. After 14 days, only the group treated with laser therapy in the
infrared spectrum showed higher bone density. No differences were
observed between groups after 21 days. Such results suggest the positive
effect of low-level laser therapy in bone repair is time- and
wavelength-dependent. In addition, our results have confirmed that
optical densitometry technique can measure bone mineralization status.
Lasers Med Sci. 2012 May 3. [Epub ahead of print]
Low-level laser therapy induces the expressions of BMP-2, osteocalcin, and TGF-?1 in hypoxic-cultured human osteoblasts. Pyo SJ, Song WW, Kim IR, Park BS, Kim CH, Shin SH, Chung IK, Kim YD. Source
Department of Oral and Maxillofacial Surgery, School of Dentistry,
Pusan National University, Beomeo, Mulgum, Yangsan, 626-770, Republic of
Korea.
Abstract
The aim of this study was to examine
the effect of low-level laser therapy (LLLT) on the cell viability and
the expression of hypoxia-inducible factor-1s (HIF-1s), bone morphogenic
protein-2 (BMP-2), osteocalcin, type I collagen, transforming growth
factor-?1 (TGF-?1), and Akt in hypoxic-cultured human osteoblasts. Human
fetal osteoblast cells (cell line 1.19) were cultured under 1 % oxygen
tension for 72 h. Cell cultures were divided into two groups. At the
experimental side, low-level laser (808 nm, GaAlAs diode) was applied at
0, 24, and 48 h. After irradiation, each cell culture was incubated 24 h
more under hypoxia. Total energy was 1.2, 2.4, and 3.6 J/cm(2),
respectively. Non-irradiated cultures served as controls. Comparisons
between the two groups were analyzed by t test; a p value <0.05 was
considered statistically significant. Hypoxia resulted in a decrease in
the expression of type I collagen, osteocalcin, and TGF-?1
(p?<?0.001, p?<?0.001, and p?<?0.01, respectively). Cell
viability and BMP-2 expression were not decreased by hypoxic condition.
On the other hand, LLLT on hypoxic-cultured osteoblast promoted the
expression of BMP-2, osteocalcin, and TGF-?1 (p?<?0.05, p?<?0.01,
and p?<?0.001, respectively). Cell proliferation was also increased
time-dependently. However, hypoxia decreased in type I collagen
expression (p?<?0.001), and LLLT did not affect type I collagen
expression in hypoxic-cultured osteoblasts. Furthermore, LLLT inhibited
HIF-1 and Akt expression in hypoxic conditioned osteoblasts. We
concluded that LLLT induces the expression of BMP-2, osteocalcin, and
TGF- ?1 in 1 % hypoxic-cultured human osteoblasts.
J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):603-14. Effect of low-level laser irradiation on osteoblast proliferation and bone formation.
Grassi FR, Ciccolella F, D’Apolito G, Papa F, Iuso A, Salzo AE,
Trentadue R, Nardi GM, Scivetti M, De Matteo M, Silvestris F, Ballini A,
Inchingolo F, Dipalma M, Scacco S, Tetè S.
Source
Department of Clinical Methodology and Medical Surgery Technology, University of Bari, Bari, Italy.
Abstract
Applications of laser therapy in biostimulation and healing injured
tissues are widely described in medical literature. The present study
focuses on the effects of laser irradiation on the growth rate and
differentiation of human osteoblast-like cells seeded on titanium or
zirconia surfaces. Cells were laser irradiated with low therapeutical
doses at different intervals and the effects of irradiation were
evaluated at each time-point. After 3 hours lasered cells showed an
enhanced mitogen activity compared to non-lasered control cells and a
higher alkaline phosphatase activity, marker of bone formation. At the
same time, the mRNA of RUNX2 and OSTERIX, two genes involved in
osteoblast differentiation, showed a clear decrease in lasered cells.
This reached the lowest value 6 to 12 hours after irradiation, after
which the transcripts started to increase, indicating that the laser
treatment did promote the osteogenic potential of growth-induced cells.
These results indicate that Low Level Laser Treatment (LLLT) stimulates
osteogenic cell proliferation.
Tinnitus= symptomer og regnes ikke som diagnose men som indre ørets lidelser.
Det indre øret har høyt spesialiserte celler og er et komplisert organ.
I det indre øret er det ca 20 000 reseptor celler som reagerer på lyd. Det er lyd reseptor
celler i det indre øret som svarer på spesielle frekvenser og det er
bred bånd reseptorer. Sammen skaper de en kompleks impuls flyt som blir
behandlet i hjernen og da oppleves som lyd.
BIOSTIMULERENDE laserlys - vitenskapelig grunnlag
Biiostimulerende behandlings studier i laser medisin har vært medisinsk
gjennomført siden 1961. Det er mer enn #3000 studier# over #lasernes # #positive# #bio-stimulerende
effekter. På Hydarpasa Military Hospital gjennomførte man laserbehandlings studie på kronisk
tinnitus pasienter, og de gjorde en stor# Gold Standard #studie#hvor resultatene ble positive.
M. PROCHÃZKA & A. HAHN - FORSKNINGSSTUDIE OM TINNITUSBEHANDLING I â€
Comprehensive Laser Rehabilitation Therapy of Tinnitus: Long-Term
Double Blind Study in a Group of 200 Patients in 3 Years †presenterar
Miroslav Procházka, Med. Dr., Private Rehab Clinic â€Jarovâ€, Prague, CZ
och Prof. PhD. Med. Dr. Aleš Hahn, ENT Clinic, FNKV Faculty Hospital,
Prag, Tjeckien, gav enda bedre resultat enn i Procházkas forrige studie.
Den senere studien går over en lengre tid og har flere pasienter som
behandles. i genomsnitt flere tilfeller enn i den første studien. Den
viser at pasienter som får en liten, men tydelig behandlingseffekt etter
en behandlingsperiode, i mange tilfeller får en større forbedring ved
gjentatt behandlingsperiode.
Vi behandler indre ørets lidelser- etter viteskapelige studier og erfaring.
Below are some LASER therapy studies within Audiology and ORL (103 pcs).
1: Andersen F, Deterville G. Evaluation of dysfunction grade using Soft Laser . IHA-GfK AG, Hergiswil, 2005: 9405696/1013051.
2: Belkahia A. Biological effects of laser beams in otolaryngology.
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88 (9): 467-473.
3: Berezin I, Berikashvili V, Ivanov B,
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4: Beyer W, Baumgartner R, Tauber S. Dosimetric Analysis for
Low-Level-Lasertherapy (LLLT) of the Human inner Ear. Proc BiOS
Europe'98, 8-12 Sept 1998, Stockholm, Sweden.
5: Beyer W,
Baumgartner R, Tauber S. Dosimetric analysis for low-level-lasertherapy
(LLLT) of the human inner ear at 593nm and 633nm. Proc. SPIE Vol. 3569,
p. 56-59, Effects of Low-Power Light on Biological Systems IV, Giovanni
F. Bottiroli; Tiina I. Karu; Rachel Lubart; Eds. (SPIE Homepage)
Publication Date: Dec 1998.
6: Bogomilskii M, Fitenko L,
Diakonova I, Tikhomirov A, Minasian V. Effects of low-energy laser
irradiation on the functional state of the acoustic analyzer. Vestnik
Otorinolaringol. 1989; 2: 29-34.
7: Bykov V, Martyniuk L.
Low-energy laser irradiation in the complex treatment of patients with
ear diseases. Voprosy Kurortologii, Fizioterapi i Lechebnoi Fizicheskoi
Kultury. 1985; (2): 60-62.
8: Backman M. LASER therapy in the
combined treatment of hyperacusis, a prospective clinical study - a
preliminary report from a clinical pilot study. Oral presentation,
Neurootological and Equilibriometric Society, International Tinnitus
Symposium, Prague, the Czech Republic, 30th March, 2004.
9:
Backman M. Hyperacusis Treatment with a Combination of Low Level Laser
light, Anti-Oxidant Control and Pulsed Electromagnetic Field - A
Clinical Pilot Study.Journal of Vestibular Research. 2004; (14) 2/3:
184.
10: Backman M. Hyperacusis as a Treatment Modality . Otoneurological Days, Prague, March 2005.
11: Backman M. LASER therapy in the combined treatment of hyperacusis, a
prospective clinical study on 245 observations. Oral presentation at
the LASER medical congress, LASER PRAHA, 17th September 2005, European
Medical Laser Association, Prague, 2005.
12 : Cuda D, De Caria
A. Combined counselling and low level laser stimulation effectiveness in
the treatment of disturbing chronic tinnitus. Diagnosis and Treatment
Tinitus Center (CeSCA) Department of Otolaryngology, Guglielmo da
Saliceto Hospital, Piacenza Hospital, Piacenza, Italy.Accepted for
Publication year 2008 in The International Tinnitus Journal.
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14:
Flock A, Flock B, Fridberger A, Scarfone E, Ulfendahl M. Supporting
cells contribute to control of hearing sensitivity. J Neurosci. 1999 Jun
1; 19 (11): 4498-4507.
15 : Fridberger A, Ren T. Local
mechanical stimulation of the hearing organ by laser irradiation.
Neuroreport. 2006 Jan 23; 17 (1): 33-37.
16: Funai H, Hara M,
Nomura Y. An electrophysiological study on the effect of laser
irradiation of round window membrane in the guinea pig. Acta Otolaryngol
Suppl. 1988; 456: 92-97.
16 :Gable P. A pilot study on Low
Level Laser Therapy (LLLT) for otitis externa - swimmers ear.
Implications for competitive swimmers. Proc. WALT 2002, Tokyo, Japan,
June 2002.
17: Gogeliia A. Efficiency of Low Level Laser
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April/June, Volume 2, Issue 2 , 151-153.
18: Gogeliia A,
Chabashvili N, Matiashvili M, Kasradze P. Experience on treatment of
children with otorhinolaryngological diseases by low intensity laser
irradiation. Georgian Med News. 2006; (130): 84-86.
19: Gungor
A, Dogru S, Cincik H, Erkul E, Poyrazoglu E. Effectiveness of
transmeatal low power laser irradiation for chronic tinnitus. Journal of
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presentation at Bárány Society Meeting in Bell Harbor International
Conference Center, Seattle, Washington State, USA. September 26-29,
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22: Hahn A, Radkova L, Achiemere G, Klement V, Alpini D,
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26: Hubacek J.: Experience with the Use of LLLT in ENT Medicine. Laser Partner 2000; No. 22.
27: Izzo A, Richter C, Jansen E, Walsh J. Laser Stimulation of the
Auditory Nerve. Lasers in Surgery and Medicine. 2006; 38 (8): 745-753.
28: Izzo A, Suh E, Pathria J, Walsh J, Whitlon D, Richter C.
Selectivity ofneural stimulation in the auditory system: a comparison of
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29: Izzo A, Walsh J, Jansen E, Bendett M, Webb J, Ralph H, Richter C.
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30: Izzo A, Walsh J, Ralph H,
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33: Jovanovic S, Jamali Y,
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34: Karabaev E,
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42: Lin S, Sun A, Tian S, Cao P.Occlusion the
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45: Medlicott M,
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47: Mishenkin N, Tikhomirov V,
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48:
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371-377. PubMed - PMID: 19821704.
103: Zazzio M. Light
penetration of the tissue of the hearing organ on pig irradiating with a
650 nm LASER light probe from outside the tympanic membrane. Evidence
material published on the Internet in November 2006 at www.alir.nu/medicin.
The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial
Innledning : Lav - nivå laserterapi ( lllt ) er antatt å ha en
analgetisk virkning , samt en biomodulatory virkning på mikrosirkulasjonen.
Denne studien er designet for å undersøke en smertelindrende effekt av
LLLT og mulige microcirculatory endringer målt ved termografi hos
pasienter med artrose ( KOA ) .
Materialer og metoder :
Pasienter med mild eller moderat KOA ble randomisert til å få enten LLLT
eller placebo LLLT . Behandlinger ble levert to ganger i uken over et
tidsrom på 4 wk med en diode laser (bølgelengde 830 nm , kontinuerlig
bølge , strøm 50 mW ) i kontakt med huden i en dose på 6 J / punkt.
Den placebo kontrollgruppe ble behandlet med et lite effektiv probe
(power 0,5 mW ) av samme utseende. Før eksamen og umiddelbart , 2 wk ,
og to mo etter fullført behandling , ble termografi utført ( bilateral
komparativ thermograph av AGA infrarødt kamera ) , felles fleksjon ,
omkrets , og trykkfølsomhet ble målt , og den visuelle analoge skala ble
registrert.
Resultater: I gruppen som ble behandlet med
aktiv LLLT , ble en betydelig forbedring funnet i smerte ( før
behandling [ BT ] : 5,75 ; 2 mnd etter behandling : 1,18 ) ; omkrets (
BT : 40.45 ; AT : 39.86 ) , trykkfølsomhet ( BT : 2,33 ; AT : 0,77 ) ,
og fleksjon ( BT : 105.83 ; AT : 122,94 ) .
I placebogruppen ,
endringer i ledd fleksjon og smerter ikke var signifikant.
Termografiske målinger viste minst 0,5 ° C økning i temperaturen , og
dermed en forbedring av sirkulasjonen i forhold til de opprinnelige
verdier . I placebo -gruppen, men disendringer ikke forekomme.
Konklusjon: Resultatene viser at lllt reduserer smerte i KOA og
forbedrer mikrosirkulasjon i det bestrålte området.
Jeg ønsker å dele følgende med dere, og håper så mange som mulig leser
det: Jeg går mye på ski (langrenn), og trener hele året for å holde meg i
form og delta på det årlige klubbmesterskapet i Søre Trysil. Der har
jeg vunnet min klasse flere ganger siden 1997. Dette året fikk jeg
problemer med mitt venstre kne, og trodde at nå må jeg "legge inn årene"
m.h.t. aktiv skiløping - og trening...
Først var jeg hos naprapat på Majorstuen, og han kunne konstatere at jeg
hadde ganske mye "slingring" i begge knærne mine. Han trykket på endel
punkter, ga meg noen gode råd og satte en tape på beinet på innsiden.
Jeg ble noe bedre da, men smertene kom tilbake. Jeg reiste så til
Toppidrettssenteret i Oslo for å få hjelp, men da jeg ikke er
toppidrettsutøver kunne de kun sende meg videre - til NIMI - Norsk
Idrettsmedisinsk Institutt på Ekeberg. En av Norges dyktigste leger på
området hadde sluttet der og begynt i Best Helse på Nordstrand. Jeg
ringte dit for å bestille time, men de skulle ha kr. 1.190,- for første
time - og jeg hadde liten tid før klubbmesterskapet skulle arrangeres -
tradisjonen tro hver påskelørdag. Derfor måtte jeg finne en annen
løsning, og kom plutselig på at jeg kjente Anne Harila fra tidligere.
Jeg ringte så henne og spurte om hun kunne hjelpe meg med det vonde
kneet - og sa "ja"... Vel, jeg må innrømme at jeg var ganske skeptisk -
men for å gjøre en lang historie veldig kort: Etter 10 behandlinger hos
Anne Harila på hennes klinikk i Sandvika ble alle smertene borte, kneet
fungerte 100% - og jeg fikk sølv i klubbmesterskapet påskelørdagen +
kunne kjøre slalåm i Trysilfjellet 2 dager på rad - fra toppen og ned -
uten pause - uten en eneste smerte i kneet. NÃ¥ i skrivende stund - 22.
april - er mitt kne like bra - og jeg skal nå på en treningstur. Behøver
jeg å si noe mer...!?
Laserbehandling er uten bivirkninger, og
virker på linje med betennelsesdempende medisiner. Medisinske
tidsskriftet The Lancet publiserte dette i 2009.
LLLT- mot candida albicans, som mange sliter med etter f.eks. amalgamfyllinger.
Photomed Laser Surg. 2014 Jun;32(6):322-9. doi: 10.1089/pho.2012.3387. Effects of low-level laser irradiation on the pathogenicity of Candida albicans: in vitro and in vivo study.
Did you know that Wayne Rooney did get treated
with LLLT (Low level laser terapy) before the football world cup 2006?
Every experts said that Rooney would not be playing the group stages in
the World cup, but guess what? He did play all the games for England in the World Cup!
Case reports on two patients whose unrelenting
facial pain and hypersensitivity from their diagnosed trigeminal
neuralgia resolved with low-level laser therapy.
FAG AKTUELT Laser gir kraftig smertelette ved akutt prolaps
Lavenergi laser og betennelsesdempende legemidler gir dobbelt så stor smertelette som slike midler aleine ved akutt prolaps i korsryggen, ifølge en stor og robust studie i tidsskriftet Pho- tomedicine and Laser Surgery (1).
TEKST Kjartan VÃ¥rbakken Fysioterapeut, MSc fal5redaktor@fysio.no
RESULTATET utfordrer den norske ryggret- ningslinjen fra 2007 som i tillegg til generell aktivitet anbefaler å starte med paraeetamol, eventuelt i kombinasjon med opoid, eller direkte med tramadol, og ved utilfredsstil- lende smertelindring etter 6-12 uker, å vurdere kirurgi (2).
Laserstudien omfattet 546 pasienter, for- delt på tre grupper il 182 pasienter hver (1). Smerten i leggen før behandling i alle gruppene, var 77 mm i gjennomsnitt på en O til 100 mm visuell analog skala fra best til verst. Smerten i leggen før behandling i alle gruppene, var om lag 77 mm i gjennomsnitt på en O til 100 mm visuell analog skala fra best til verst. Smerten gikk i gjennomsnitt ned for gruppene:
Laser og betennelsesdempende med 44 mm betennelsesdempende alene med 21mm placebo laser med 17 mm Størrelsen på ekstraeffekten med laser var altså 23 mm i gjennomsnitt i forhold til betennelsesdempende alene, mens denne ekstraeffekten generalisert til «alle med ner- verotsmerter» varierer bare mellom 21 og 24 mm (95 prosent konfidensintervall). Ef- fektstørrelsen var høy (punkteffekt 3.8, hvor nedre grense for høy er 0.8). Akutt fase var definert som fra skaden oppsto til og med fire uker.
Michael Hamblin is a principal investigator at
the Wellman Center for Photomedicine at MGH and an associate professor
of dermatology at Harvard Medical School. His research program in
photodynamic therapy and low-level laser therapy is supported
by the National Institutes of Health, Congressionally Directed Medical
Research Programs, and Center for Integration of Medicine and Innovative
Technology. He has published more than 125 peer-reviewed articles.
The studies revealed that low-level laser therapy could be considered
in treatment of trigeminal neuralgia. Laser causes pain relief without
any side effects. It could be helpful especially in patients
suffering from neuralgia tolerated to drug therapy. It should be
mentioned that distinguishing neuralgia from other chronic pain such as
atypical facial pains is important in effectiveness of treatment.
